The MPI Research Department
of Infusion Toxicology has the expertise
and technology to conduct intravenous infusion
(IV) studies in mice, rats, rabbits, dogs,
mini-pigs, and nonhuman primates. The preclinical
safety evaluation of a drug via intravenous
infusion is typically used to mimic the route
of administration and dose regimen intended
for human use.
Difficulties encountered with drugs of poor
solubility and/or poor bioavailability when
administered via another route can necessitate
the use of IV infusion to achieve higher
systemic multiples of the clinical dose and/or
to control the Cmax value.
The IV infusion allows for larger volumes
to be administered over a longer period of
time. By adjusting concentration and dose
volume, it is possible to increase the tolerability
of a drug. The use of a larger blood vessel
such as the vena cava also permits a greater
dilution of the drug and reduces the potential
for irritation due to a low or high pH.
Based on the intended duration of treatment
(i.e., from a few minutes up to a continuous
24 hours/day), dosing can be either performed
in restrained animals via a peripheral vein
or using the jacket tether system. For the
latter, a medical-grade catheter is implanted
in the vena cava via the femoral vein, or into
the jugular vein, then passed subcutaneously
and exteriorized in the back of the animal.
The catheter is passed through the tether and
connected to a rotating swivel attached to
the cage, which allows the animal to move freely.
On the opposite side of the swivel, short tubing
with an injection cap is connected to the syringe
or volumetric infusion pump.
Services/Capabilities
- Customized study designs
- Robust infusion models, allowing for design flexibility in multiple species
- Ambulatory infusion
- Jacket-tether infusion
- Peripheral vein infusion
- Acute and subchronic toxicology studies
- Animal models utilizing rats, rabbits, dogs, and non-human primates
- Surgical capabilities with access to MPI Research surgical department and facilities
- Dedicated infusion surgical suite (for surgery and catheter repair)
- Dedicated surgical support
- Experienced veterinary staff
- MPI Research surgeons (ASR certified)
- Medical-grade catheters
For more detailed information about the
infusion toxicology services offered by MPI
Research, please contact Infusiontoxicology@mpiresearch.com or
call 269.668.3336, Ext. 1793.
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